芝麻素--黑芝麻提取物

Sesamin--Black Sesame Extract Sesamum indicum L

Sesamin Herb Source
Sesamum indicum L. Zanthoxylum acanthapodium var. villosum Huang. Piper longum

Molecular Formula and Molecular Weight
C20H15O6/351.34

Formula Structures:

Melting Point:122 -123
Assay: ≥99%
CAS NO.: 607-80-7
Solubility:sesamin Freely soluble in chloroform-benzene-acetic acid and acetone.

Sesamin Pharmacology

1. Antioxidant: Sesamin helps protect blood vessels by scavenging free radicals and ensuring efficient nutrient and oxygen delivery for healthy brain function.
2. Bactericide
3. Insecticide
4. Decreasing fat storage 
5. Antihypertensive: Sesamin induces nitric oxide and decreases endothelin-1 production in HUVECs, possible implications for its antihypertensive effect.
6. Provide liver protection against alcohol and improve liver function:Sesamin is a non-competitive inhibitor of Δ5-desaturase, It inhibits the conversion of DGLA to arachidonic acid, and consequently decreases the formation of proinflammatory 2-series prostaglandins.
7. Decrease cholesterol levels, while increasing high density lipoprotein (HDL aka "good cholesterol") levels
8. Be an anti-inflammatory
9. Skin problem: The experiments in rats shows that sesamin can inhibit the growth of SC (skin cancer) cell. It can protect skin from UV rays.

HPLC Chromatogram Spectrum

Bio-samin The best Sesamin you can trust

Our sesame oil is pressed from 100% natural black sesame seed without any impurity.

Sesamin—Famous company pay attention to

• Suntory Ltd (Japan)
  • Protect Liver , anti-cancer 
• Scvition (USA)
  • Maximize Fat Loss , Promote Liver and Kidney Health 
• Singapore Cerebos Pacific (Brands)
  • Protect Liver, Anti-Oxidant , Antihypertensive

Bio-samin—OHI's pride

• Based on the expectable brilliant future of Sesamin and the going up market of Sesamin, OHI started to research and develop Sesamin in October, 2002.
• OHI put sesamin into industrial scale production in February, 2003 with thanks to the hard work and intelligence of OHI’s R&D people.
• Advanced technology and equipment are applied in our manufacturing process.
• OHI sign up with Shaoyang city government to crop 30,000 hectares black sesame.
• OHI has its own in-house lab to analysis Sesamin by HPLC

Manufacturing process of OHI Bio-samin

Sesamin--Study

1. Suntory, Ochanomizu University Jointly Confirm That Sesamin Helps Lower Blood Sugar Level,Tokyo, June 29, 2006 (JCN) - Suntory, in collaboration with Ochanomizu University, has confirmed a unique property of sesamin. Sesamin is a kind of lignan compound which is contained only in sesame seeds.
   
   In experiments using obese rats, the two partners confirmed that sesamin substantially lowers the level of blood sugar.
   
   Details of the joint research were presented at the 14th Meeting of the International Atherosclerosis Society, held in Italy from June 19 to 22, under the title of "Sesamin reduced blood glucose concentrations in Zucker fatty rats".
   
   Sesamin is known to have a variety of properties including lowering cholesterol levels, inhibiting hypertension, antioxidation and immune regulation.
2. Sesamin induces nitric oxide and decreases endothelin-1 production in HUVECs: possible implications for its antihypertensive effect.
   
   Sesamin has been proved to be antihypertensive. Nitric oxide (NO) is the most important vascular relaxing factor that is regulated in endothelium. Endothelin-1 (ET-1) is characterized as a potent vasoconstrictor and is also regulated in endothelium. Alterations in the endothelial production of NO and ET-1 are known to correlate with hypertension. This study investigated the effect of sesamin on NO and ET-1 in the human umbilical vein endothelial cells (HUVECs). DESIGN: The concentrations of NO and ET-1 in the medium of HUVECs treated by sesamin were measured. The mRNA and protein expressions of nitric oxide synthase (NOS), endothelin converting enzyme-1 (ECE-1), and endothelin-1 (ET-1) were also investigated. Other than the mRNA and protein expression, NOS activity and cyclic GMP (cGMP) were detected. METHODS: The NO concentration was detected by colorimetric assay. The cGMP and ET-1 were analyzed by EIA. The eNOS, ECE-1, and ET-1 mRNA expressions were assayed by Northern blot. The eNOS and ECE-1 protein expressions were analyzed by Western blot. The NOS activity was assayed by detecting the level of [H]-1-citrullin transformed from [H]-1-arginine. RESULTS: Sesamin not only increased the NO concentration in the medium of HUVECs in a dose-dependent manner after 24 h, but also induced eNOS mRNA and protein expressions. NOS activity in the HUVECs was also induced by sesamin. The content of cGMP was induced by sesamin through NO signaling. On the other hand, the ET-1 concentration in the medium of HUVECs treated by sesamin was suppressed in a dose-dependent manner after 24 h. The ECE-1 protein and mRNA expressions were also inhibited by sesamin. However, the mRNA expression of prepro ET-1 was not influenced by sesamin. CONCLUSION: From the above results, it is suggested that sesamin may improve hypertension by its ability to induce NO and inhibit ET-1 production from endothelial cells. The increase of NO by sesamin is through the induction of eNOS gene expression. The decrease of ET-1 by sesamin is through the inhibition of ECE gene expression, but is not through the inhibition of prepro ET-1 gene expression.
3. Akimoto K. et al. Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann. Nutr. Metab. 1993; 37:218-24
4. Shimizu S. and Akimoto K. Effect of sesamin on the thermogram of the human subjects after drinking ethanol. Biosci. Ind. 1993; 51:7-8.
5. Hirose N. et al. Suppressive effect of sesamin against 7,12-dimethylbenz [a]-anthracene induced rat mammary carcinogenesis. Anticancer Res. 1992; 12:1259-66.
6. Hirose N. et al. Inhibition of cholesterol absorption and synthesis in rats by sesamin. J.Lipid Res. 1991; 32:629-38

Sesamin—experimenting in animals and humans

1. The effects of sesamin, a lignan from sesame oil, on various aspects of cholesterol metabolism were examined in rats maintained on various dietary regimens.
   N Hirose, T Inoue, K Nishihara, M Sugano, K Akimoto, S Shimizu and H Yamada Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan
2. Suntory, NTT West, Kyoto Hospital
   Jointly Confirm Sesamin Helps Reduce Blood Pressure, Leading Japanese beverage
   manufacturer Suntory announced on August 26
3. Suntory Health Care Science Laboratory (Shimamoto Town, Osaka Prefecture), together with Prof. Kanae Yamashita of Sugiyama Jogakuen University, has confirmed the effectiveness of sesamin, one of the major lignan compounds contained in sesame, for preventing skin troubles from ultraviolet (UV) rays by increasing the concentration of tocotrienol, a homolog of vitamin E, in the skin.

Why Organic Herb Inc. Sesamin:

• A.) Organic Herb Inc. Sesamin is 100% extracted from natural sesame seed oil very safe and more bioactive.
• B.) Organic Herb Inc. have the most purity Sesamin, Our Sesamin is a 99% purity product tested by HPLC and just one peak on HPLC chromatogram.
• C.) Organic Herb Inc. Sesamin almost have no unpleasant taste compare to other Sesamin and it can be easier to take by oral.
• D.) Organic Herb Inc. offer Sesamin at a very lower price with a very high and uniform quality.
• E.) More important --- we have a very large output to meet our customers' big and continual orders.